A Nonconventional Analysis of CD$4^{+}$ and CD$8^{+}$ T Cell Responses During and After Acute Lymphocytic Choriomeningitis Virus Infection

A mathematical model from a previous work was re-fitted and analyzed for experimental data regarding the cellular immune response to the lymphocytic choriomeningitis virus. Specifically, the CD8 T cell response to six MHC class I-restricted epitopes (GP* and NP*) and CD4 T cell responses to two MHC class II-restricted epitopes[2]. In this work, we use calibration through log likelihood maximization to investigate if different parameters can produce a more accurate fit of the model presented previously in the paper titled Different Dynamics of CD4 and CD8 T Cell Responses During and After Acute Lymphocytic Choriomeningitis Virus Infection[2].